DIRECTOR STRUCTURAL/FUNCTIONAL BIOLOGY

Are you someone who is passionate about understanding the role of a protein in disease – especially genetic diseases? Have you applied various approaches (protein modeling, biochemistry, characterization, etc.) to better understand the role of a mutated protein in pathogenesis. We are looking for an accomplished and collaborative scientific problem solver who will bring innovative thinking to solving underlying questions related to onset and progression of disease. S/he will help establish strategic priorities, plan experiments to test hypotheses, and oversee execution of genetic and biochemical investigations of a specific mutant protein Experience in neurodegenerative disease is a plus. The position offers a unique team environment focused on quickly identifying targets and advancing therapeutics.

Role and Responsibilities:

  • Play a significant role in refining and evolving the strategic plans for experimental investigation of the function of a mutated protein with an initial primary focus on Post-translational modifications (PTM), enzymes modulating PTMs and protein:protein interactions
  • Manage a collaborative network of contract research and academic scientists engaged in an integrated portfolio of projects to interrogate protein function and identify and evolve new collaborations.
  • Critically design experiments, analyze and synthesize data sets
  • Identify candidate protein therapeutic targets/mechanisms and design and oversee Target validation experimental plans
  • Contribute to bringing forward drug discovery candidates
  • Provide biology co-leadership of integrated Med chem programs with therapeutic relevance to modulating pathogenic genetic dysfunction
  • Advance experimental approaches including established and emerging technologies in cells, tissues, and animals (e.g. yeast two hybrid, antibody/aptamer based technologies, bioinformatics, genome and protein engineering, protein labeling, and mass spectroscopy).
  • Contribute as a member of a multidisciplinary team to the evaluation, prioritization, and implementation of biophysical, biochemical, and proteomics platforms.
  • Participate in internal and external team meetings to evaluate and advance the validation of targets, outcome measures, and models for (HD) drug discovery
  • Pro-actively identify, source, and integrate capabilities and competencies for current and future programs in the areas of protein function,  new assay development, and candidate drug molecule candidates for therapeutic advancement
  • High level management/oversight of external contract research organizations, biotechnology collaborators, and academic laboratories
  • Participate in internal and external scientific reviews
  • Fulfill necessary process, legal, and business requirements to enable our scientific efforts
  • Communicate the state-of-the art opportunities protein function to accelerate an understanding of the disease biology and candidates for treatments to internal and external parties
  • Engage collaboratively with internal team members and external partners

Requirements:

The candidate of choice will have:

  • A Ph.D. in life sciences and relevant postdoctoral training with a minimum of 5 years of experience as an independent scientist
  • Significant experience in planning and conducting in vitro, in vivo, and ex vivo genetic, biochemical and pharmacologic perturbation studies directed towards elucidating protein biological mechanism of action, optimally with experience in the central nervous system and neurodegeneration
  • Expertise in investigating protein post-translational modifications and upstream signaling cascades and PTM modifying enzymes (kinases, phosphatases, acetylases etc.)
  • Experience and accomplishment in elucidating protein complexes and their cellular function(s)
  • Knowledge and experience in the design and characterization of protein isolation and characterization technologies
  • Experience with proteomics and mass spectroscopy experimental design data analysis
  • Expertise in molecular biology
  • Significant experience in planning and conducting in vitro, in vivo, and ex vivo genetic, biochemical and pharmacologic perturbation studies directed towards elucidating protein biological mechanism of action, optimally with experience in the central nervous system and neurodegeneration
  • Drug discovery experience in validating targets for therapeutic advancement
  • Familiarity with contemporary ‘omics technology platforms and data analyses

Personal Qualities:

  • Ability to identify, design, and drive innovative programs
  • Demonstrated evidence of scientific “problem solving”
  • Strong analytical skills, critical reasoning, and scientific rigor
  • Excellent written and oral communication skills, and effective interpersonal skills necessary for the coordination of a large network of external global collaborators
  • Evidence of being highly self-motivated and an ability to work independently AND collaboratively
  • Ability to travel to Los Angeles CA office as well globally and nationally to interact with collaborators

Preferred Skills:

A compelling candidate would also have:

  • Experience in the biopharmaceutical sector
  • Experience working on neurodegenerative diseases
  • Neuroscience knowledge and expertise
  • Experience in assay development and adaptation to high throughput biology with experience in enzymology
  • Experience in contributing efficacy and translational data for IND filing packages
  • Track record of accountability for managing/overseeing external collaborators and collaborations
  • Training and knowledge in biophysical and structural biology
  • Familiarity with computational protein modeling
  • Training and knowledge in genetics
  • Experience in bioinformatics mining

To apply for this position, confidentially email us here.